A03-Moleculas Bioactivas
Oncología / IBS-A03
El grupo se dedica al diseño y síntesis de fármacos antitumorales. El estudio de las relaciones estructura-reactividad nos permite afinar las estructuras de los prototipos, incrementándose la actividad antiproliferativa y disminuyéndose la toxicidad.
Líneas de investigación
- Estructuras homoquirales obtenidas a partir de bencenos disustituidos en posición orto, con actividad antitumoral
- Nuevos compuestos con actividad antitumoral como inhibidores de colina quinasa
Palabras clave
Heterociclos de seis y siete miembros, fármacos antitumorales, purinas
MARIA ENCARNACION CAMACHO QUESADA
JOAQUIN MARIA CAMPOS ROSA
MARIA DORA CARRION PEREGRINA
ANA CONEJO GARCIA
OLGA CRUZ LOPEZ
Inventores: ARANEGA JIMENEZ ANTONIA ; BOULAIZ HOURIA ; CAMPOS ROSA JOAQUIN MARIA ; CATIVIELA MARIN CARLOS ; CHOQUESILLO-LAZARTE DUANE; CONEJO GARCIA ANA ; CRUZ LOPEZ OLGA ; GARCIA CHAVES MARIA ANGEL ; GARCIA RUIZ JUAN MANUEL ; JIMENEZ SANZ ANA ISABEL; MARCHAL
Título: DIANAS BENZOHETEROEPINICOS
Código: P201030415
Inventores: Campos JM; Lopez l; Marchal JA; Boulaiz H; Aránega A; Gallo MA; Espinosa A; Rodríguez-Serrano F; Conejo, Ana
Título: NUEVAS (RS)- 7- O 9- (1,2,3,5- TETRAHIDRO-4,1-BENZOCAZEPIN-3-IL)-7H O9H-PURINAS CON ACTIVIDAD ANTITUMORAL
Código: P200802431
Inventores: ARANEGA JIMENEZ ANTONIA ; CAMPOS ROSA JOAQUIN ; ESPINOSA UBEDA ANTONIO ; GALLO MEZO MIGUEL ANGEL ; GOMEZ VIDAL JOSE ANTONIO ; NUNEZ CARRETERO M DEL CARMEN; MARCHAL CORRALES JUAN ANTONIO; Rodriguez-Serrano F ;
Título: (2,3-DIHIDRO-5H-1,4-BENZODIHETEROEPIN-3-IL)PURINAS CON ACTIVIDAD ANTITUMORAL
Código: P200601538
Título: DIANAS BENZOHETEROEPINICOS
Código: P201030415
Inventores: Campos JM; Lopez l; Marchal JA; Boulaiz H; Aránega A; Gallo MA; Espinosa A; Rodríguez-Serrano F; Conejo, Ana
Título: NUEVAS (RS)- 7- O 9- (1,2,3,5- TETRAHIDRO-4,1-BENZOCAZEPIN-3-IL)-7H O9H-PURINAS CON ACTIVIDAD ANTITUMORAL
Código: P200802431
Inventores: ARANEGA JIMENEZ ANTONIA ; CAMPOS ROSA JOAQUIN ; ESPINOSA UBEDA ANTONIO ; GALLO MEZO MIGUEL ANGEL ; GOMEZ VIDAL JOSE ANTONIO ; NUNEZ CARRETERO M DEL CARMEN; MARCHAL CORRALES JUAN ANTONIO; Rodriguez-Serrano F ;
Título: (2,3-DIHIDRO-5H-1,4-BENZODIHETEROEPIN-3-IL)PURINAS CON ACTIVIDAD ANTITUMORAL
Código: P200601538
Identification of Potential Inhibitors from Pyriproxyfen with Insecticidal Activity by Virtual Screening
PHARMACEUTICALS, 2019;
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019;
FI:4,833; D1
In Silico Evaluation of Ibuprofen and Two Benzoylpropionic Acid Derivatives with Potential Anti-Inflammatory Activity
MOLECULES, 2019;
FI:3,06; Q2
Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism
MOLECULES, 2019;
FI:3,06; Q2
Identification of New Inhibitors with Potential Antitumor Activity from Polypeptide Structures via Hierarchical Virtual Screening
MOLECULES, 2019;
FI:3,06; Q2
Enhancement of Tumor Cell Death by Combining gef Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells
FRONTIERS IN PHARMACOLOGY, 2018;
FI:3,831; Q1
Syntheses of non-aromatic medium and large rings synthesized via phenylnitrenium ions
ARABIAN JOURNAL OF CHEMISTRY, 2018;
FI:2,969; Q2
Cysteine-based 3-substituted 1,5-benzoxathiepin derivatives: Two new classes of anti-proliferative agents
ARABIAN JOURNAL OF CHEMISTRY, 2018;
FI:2,969; Q2
Development of Biotransamination Reactions towards the 3,4-Dihydro-2H-1,5-benzoxathiepin-3-amine Enantiomers
CATALYSTS, 2018;
FI:3,465; Q2
An In Silico Study of the Antioxidant Ability for Two Caffeine Analogs Using Molecular Docking and Quantum Chemical Methods
MOLECULES, 2018;
FI:3,098; Q2
1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds
FUTURE MEDICINAL CHEMISTRY, 2017;
FI:3,556; Q1
Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells
FUTURE MEDICINAL CHEMISTRY, 2017;
FI:3,556; Q1
Metal binding pattern of acyclovir in ternary copper(II) complexes having an S-thioether or S-disulfide NO2S-tripodal tetradentate chelator
INORGANICA CHIMICA ACTA, 2016;
FI:1,918; Q2
H-1 and C-13 NMR spectral data of p-nitrobenzenesulfonamides and dansylsulfonamides derived from N-alkylated o-(purinemethyl)anilines
MAGNETIC RESONANCE IN CHEMISTRY, 2016;
FI:1,226; Q3
The use of wiki to promote students’ learning in higher education (Degree in Pharmacy)
INTERNATIONAL JOURNAL OF EDUCATIONAL TECHNOLOGY IN HIGHER EDUCATION, 2016;
Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death
SCIENTIFIC REPORTS, 2016;
FI:5,228; Q1
Inhibitors of Cancer Stem Cells
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2016;
FI:2,722; Q2
Imidazoles and Benzimidazoles as Tubulin-Modulators for Anti-Cancer Therapy
CURRENT MEDICINAL CHEMISTRY, 2015;
FI:3,853; D1
Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015;
FI:3,447; Q1
p-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents
RSC ADVANCES, 2015;
FI:3,84; Q1
Preclinical Characterization of RSM-932A, a Novel Anticancer Drug Targeting the Human Choline Kinase Alpha, an Enzyme Involved in Increased Lipid Metabolism of Cancer Cells
MOLECULAR CANCER THERAPEUTICS, 2015;
FI:5,683; Q1
Molecular recognition between adenine or 2,6-diaminopurine and copper(II) chelates with N,O-2,S-tripodal tetradentate chelators having thioether or disulfide donor groups
JOURNAL OF INORGANIC BIOCHEMISTRY, 2015;
FI:3,444; Q1
Mejora de la actividad anticancerosa del bozepinib, bozinib y derivados, mediante la introducción del grupo trifluorometilo
Financiador: UNIVERSIDAD DE GRANADA
Número de expediente: UGR001/A-03
Tiempo de ejecución: 01/01/2017 - 31/12/2018
IP: JOAQUIN MARIA CAMPOS ROSA
