MP02-Farmacologia Cardiovascular

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Nuestras líneas de investigación tienen como objetivos generales: estudiar el papel del sistema inmune en la disfunción endotelial en hipertensión, buscar estrategias de modulación de la flora intestinal y su impacto integral en el control de la presión arterial. En ambos casos colaboramos con el Hospital Universitario Virgen de la Nieves de Granada y con empresas como Biosearch SA y con el Centro Tecnológico de Investigación y Desarrollo del Alimento Funcional (CIDAF).

JUAN MANUEL DUARTE PEREZ

MANUEL GOMEZ GUZMAN

ROSARIO JIMENEZ MOLEON

MIGUEL ROMERO PEREZ

MANUEL SANCHEZ SANTOS

Hidalgo-Gutierrez, A; Barriocanal-Casado, E; Bakkali, M; Diaz-Casado, ME; Sanchez-Maldonado, L; Romero, M; Sayed, RK; Prehn, C; Escames, G; Duarte, J; Acuna-Castroviejo, D; Lopez, LC

beta-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9(R239X) mice

EMBO MOLECULAR MEDICINE, 2019;

FI:10,624; D1

de la Visitacion, N; Robles-Vera, I; Toral, M; Duarte, J

Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus

NUTRIENTS, 2019;

FI:4,171; Q1

Sanchez, M; Romero, M; Gomez-Guzman, M; Tamargo, J; Perez-Vizcaino, F; Duarte, J

Cardiovascular Effects of Flavonoids

CURRENT MEDICINAL CHEMISTRY, 2019;

FI:3,894; Q1

Vazquez, A; Sanchez-Rodriguez, E; Vargas, F; Montoro-Molina, S; Romero, M; Espejo-Calvo, JA; Vilchez, P; Jaramillo, S; Olmo-Garcia, L; Carrasco-Pancorbo, A; de la Torre, R; Fito, M; Covas, MI; de Victoria, EM; Mesa, MD

Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

NUTRIENTS, 2019;

FI:4,171; Q1

Robles-Vera, I; Callejo, M; Ramos, R; Duarte, J; Perez-Vizcaino, F

Impact of Vitamin D Deficit on the Rat Gut Microbiome

NUTRIENTS, 2019;

FI:4,171; Q1

Jimenez, R; Toral, M; Gomez-Guzman, M; Romero, M; Sanchez, M; Mahmoud, AM; Duarte, J

The Role of Nrf2 Signaling in PPAR beta/delta-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018;

FI:4,936; Q2

Arias, F; Camacho, ME; Carrion, MD; Chayah, M; Romero, M; Duarte, J; Gallo, MA

Thiadiazoline- and Pyrazoline-Based Carboxamides and Carbothioamides: Synthesis and Inhibition against Nitric Oxide Synthase

JOURNAL OF CHEMISTRY, 2018;

FI:1,726; Q3

Toral, M; Romero, M; Rodriguez-Nogales, A; Jimenez, R; Robles-Vera, I; Algieri, F; Chueca-Porcuna, N; Sanchez, M; de la Visitacion, N; Olivares, M; Garcia, F; Perez-Vizcaino, F; Galvez, J; Duarte, J

Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling

MOLECULAR NUTRITION & FOOD RESEARCH, 2018;

FI:5,151; D1

Robles-Vera, I; Toral, M; de la Visitacion, N; Sanchez, M; Romero, M; Olivares, M; Jimenez, R; Duarte, J

The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade

MOLECULAR NUTRITION & FOOD RESEARCH, 2018;

FI:5,151; D1

Callejo, M; Mondejar-Parreno, G; Barreira, B; Izquierdo-Garcia, JL; Morales-Cano, D; Esquivel-Ruiz, S; Moreno, L; Cogolludo, A; Duarte, J; Perez-Vizcaino, F

Pulmonary Arterial Hypertension Affects the Rat Gut Microbiome

SCIENTIFIC REPORTS, 2018;

FI:4,122; Q1

Quesada, A; Segarra, AB; Montoro-Molina, S; de Gracia, MD; Osuna, A; O'Valle, F; Gomez-Guzman, M; Vargas, F; Wangensteen, R

Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats

PLOS ONE, 2017;

FI:2,806; Q1

Recoquillon, S; Gomez-Guzman, M; Rodier, M; Koffi, C; Nitiema, M; Gagnadoux, F; Martinez, MC; Andriantsitohaina, R

Non-muscular myosin light chain kinase triggers intermittent hypoxia-induced interleukin-6 release, endothelial dysfunction and permeability

SCIENTIFIC REPORTS, 2017;

FI:4,259; Q1

Toral, M; Romero, M; Perez-Vizcaino, F; Duarte, J; Jimenez, R

Antihypertensive effects of peroxisome proliferator-activated receptor-beta/delta activation

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2017;

FI:3,348; Q2

Robles-Vera, I; Toral, M; Romero, M; Jimenez, R; Sanchez, M; Perez-Vizcaino, F; Duarte, J

Antihypertensive Effects of Probiotics

CURRENT HYPERTENSION REPORTS, 2017;

FI:3,036; Q2

Pozo, JFM; Perez, JMD; Rovira, PS

OFF-LABEL USE OF BEVACIZUMAB IN ONCOLOGY PATIENTS. INFLUENCE ON EFFECTIVENESS, SECURITY AND COSTS

FARMACIA, 2017;

FI:1,348; Q4

Morales-Cano, D; Moreno, L; Barreira, B; Briones, AM; Pandolfi, R; Moral-Sanz, J; Callejo, M; Mondejar-Parreno, G; Cortijo, J; Salaices, M; Duarte, J; Perez-Vizcaino, F; Cogolludo, A

Activation of PPAR beta/delta prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries

CLINICAL SCIENCE, 2016;

FI:5,016; Q1

Chamorro, V; Pandolfi, R; Moreno, L; Barreira, B; Martinez-Ramas, A; Morales-Cano, D; Ruiz-Cabello, J; Lorente, JA; Duarte, J; Cogolludo, A; Alvarez-Sala, JL; Perez-Vizcaino, F

Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion

MOLECULES, 2016;

FI:2,465; Q2

Marin-Pozo, JF; Duarte-Perez, JM; Sanchez-Rovira, P

Safety, Effectiveness, and Costs of Bevacizumab-Based Therapy in Southern Spain: A Real World Experience

MEDICINE, 2016;

FI:2,133; Q2

Chayah, M; Camacho, ME; Carrion, MD; Gallo, MA; Romero, M; Duarte, J

N,N ‘-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase

MEDCHEMCOMM, 2016;

FI:2,319; Q3

Zamorano-Leon, JJ; Hernandez-Fisac, I; Guerrero, S; Tamarit-Rodriguez, J; Santos-Sancho, JM; Sopena, B; Escolar, G; Lopez-Vilchez, I; Duarte, J; Barrientos, A; Lopez-Farre, AJ

New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres

TRANSPLANT IMMUNOLOGY, 2016;

FI:1,317; Q3

Toral, M; Gomez-Guzman, M; Jimenez, R; Romero, M; Zarzuelo, MJ; Utrilla, MP; Hermenegildo, C; Cogolludo, A; Perez-Vizcaino, F; Galvez, J; Duarte, J

Chronic peroxisome proliferator-activated receptor beta/delta agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity

JOURNAL OF HYPERTENSION, 2015;

FI:4,72; Q1

Jimenez, R; Lopez-Sepulveda, R; Romero, M; Toral, M; Cogolludo, A; Perez-Vizcaino, F; Duarte, J

Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats

FOOD & FUNCTION, 2015;

FI:2,791; Q1

Chayah, M; Carrion, MD; Gallo, MA; Jimenez, R; Duarte, J; Camacho, ME

Development of Urea and Thiourea Kynurenamine Derivatives: Synthesis, Molecular Modeling, and Biological Evaluation as Nitric Oxide Synthase Inhibitors

CHEMMEDCHEM, 2015;

FI:2,968; Q2

Rodríguez-Gómez I, Manuel Moreno J, Jimenez R, Quesada A, Montoro-Molina S, Vargas-Tendero P, Wangensteen R, Vargas F.

Effects of Arginase Inhibition in Hypertensive Hyperthyroid Rats.

AMERICAN JOURNAL OF HYPERTENSION, 2015;

FI:2,852; Q2

Toral, M; Romero, M; Jimenez, R; Mahmoud, AM; Barroso, E; Gomez-Guzman, M; Sanchez, M; Cogolludo, A; Garcia-Redondo, AB; Briones, AM; Vazquez-Carrera, M; Perez-Vizcaino, F; Duarte, J

Carnitine palmitoyltransferase-1 up-regulation by PPAR-beta/delta prevents lipid-induced endothelial dysfunction

CLINICAL SCIENCE, 2015;

FI:5,598; Q1

SUPLEMENTACION DIETETICA CON PROBIOTICOS, SISTEMA INMUNE E HIPERTENSION ARTERIAL

Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD

Número de expediente: SAF2014-55523-R

Tiempo de ejecución: 01/01/2015 - 31/12/2017

IP: JUAN MANUEL DUARTE PEREZ