MP02-Farmacologia Cardiovascular
Medicina de precisión / IBS-MP02
Nuestras líneas de investigación tienen como objetivos generales: estudiar el papel del sistema inmune en la disfunción endotelial en hipertensión, buscar estrategias de modulación de la flora intestinal y su impacto integral en el control de la presión arterial. En ambos casos colaboramos con el Hospital Universitario Virgen de la Nieves de Granada y con empresas como Biosearch SA y con el Centro Tecnológico de Investigación y Desarrollo del Alimento Funcional (CIDAF).
JUAN MANUEL DUARTE PEREZ
MANUEL GOMEZ GUZMAN
ROSARIO JIMENEZ MOLEON
MIGUEL ROMERO PEREZ
MANUEL SANCHEZ SANTOS
beta-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9(R239X) mice
EMBO MOLECULAR MEDICINE, 2019;
FI:10,624; D1
Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus
NUTRIENTS, 2019;
FI:4,171; Q1
Cardiovascular Effects of Flavonoids
CURRENT MEDICINAL CHEMISTRY, 2019;
FI:3,894; Q1
Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats
NUTRIENTS, 2019;
FI:4,171; Q1
Impact of Vitamin D Deficit on the Rat Gut Microbiome
NUTRIENTS, 2019;
FI:4,171; Q1
The Role of Nrf2 Signaling in PPAR beta/delta-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018;
FI:4,936; Q2
Thiadiazoline- and Pyrazoline-Based Carboxamides and Carbothioamides: Synthesis and Inhibition against Nitric Oxide Synthase
JOURNAL OF CHEMISTRY, 2018;
FI:1,726; Q3
Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling
MOLECULAR NUTRITION & FOOD RESEARCH, 2018;
FI:5,151; D1
The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade
MOLECULAR NUTRITION & FOOD RESEARCH, 2018;
FI:5,151; D1
Pulmonary Arterial Hypertension Affects the Rat Gut Microbiome
SCIENTIFIC REPORTS, 2018;
FI:4,122; Q1
Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats
PLOS ONE, 2017;
FI:2,806; Q1
Non-muscular myosin light chain kinase triggers intermittent hypoxia-induced interleukin-6 release, endothelial dysfunction and permeability
SCIENTIFIC REPORTS, 2017;
FI:4,259; Q1
Antihypertensive effects of peroxisome proliferator-activated receptor-beta/delta activation
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2017;
FI:3,348; Q2
Antihypertensive Effects of Probiotics
CURRENT HYPERTENSION REPORTS, 2017;
FI:3,036; Q2
OFF-LABEL USE OF BEVACIZUMAB IN ONCOLOGY PATIENTS. INFLUENCE ON EFFECTIVENESS, SECURITY AND COSTS
FARMACIA, 2017;
FI:1,348; Q4
Activation of PPAR beta/delta prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries
CLINICAL SCIENCE, 2016;
FI:5,016; Q1
Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion
MOLECULES, 2016;
FI:2,465; Q2
Safety, Effectiveness, and Costs of Bevacizumab-Based Therapy in Southern Spain: A Real World Experience
MEDICINE, 2016;
FI:2,133; Q2
N,N ‘-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase
MEDCHEMCOMM, 2016;
FI:2,319; Q3
New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres
TRANSPLANT IMMUNOLOGY, 2016;
FI:1,317; Q3
Chronic peroxisome proliferator-activated receptor beta/delta agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity
JOURNAL OF HYPERTENSION, 2015;
FI:4,72; Q1
Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats
FOOD & FUNCTION, 2015;
FI:2,791; Q1
Development of Urea and Thiourea Kynurenamine Derivatives: Synthesis, Molecular Modeling, and Biological Evaluation as Nitric Oxide Synthase Inhibitors
CHEMMEDCHEM, 2015;
FI:2,968; Q2
Effects of Arginase Inhibition in Hypertensive Hyperthyroid Rats.
AMERICAN JOURNAL OF HYPERTENSION, 2015;
FI:2,852; Q2
Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats
MOLECULAR NUTRITION & FOOD RESEARCH, 2015;
FI:4,603; D1
SUPLEMENTACION DIETETICA CON PROBIOTICOS, SISTEMA INMUNE E HIPERTENSION ARTERIAL
Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD
Número de expediente: SAF2014-55523-R
Tiempo de ejecución: 01/01/2015 - 31/12/2017
IP: JUAN MANUEL DUARTE PEREZ