MP09-Neurofarmacologia del Dolor
Medicina de precisión / IBS-MP09
El grupo tiene como objetivos fundamentales identificar nuevas dianas farmacológicas para el tratamiento del dolor, desarrollar nuevos modelos experimentales para la evaluación del dolor con valor traslacional, profundizar en el conocimiento de los mecanismos neuroquímicos implicados en el dolor, desarrollar nuevas estrategias de evaluación y tratamiento del dolor en clínica, así como la determinación de diversos efectos de la melatonina.
Líneas de investigación
- EVALUACIÓN DEL DOLOR Y DE PROCEDIMIENTOS ANALGÉSICOS EN HUMANOS. RECEPTORES ACOPLADOS A PROTEINAS G
- IMPLICACIÓN DE LOS RECEPTORES SIGMA1 EN LOS MECANISMOS DE PERCEPCIÓN DEL DOLOR: Estudios comportamentales y bioquímicos en modelos de dolor somático y visceral.
- MECANISMOS MOLECULARES DEL EFECTO ANTI-OBESIDAD DE LA MELATONINA EN RATA OBESA Y DIABÉTICA
MIRIAM SANTOS CABALLERO
ESPERANZA DEL POZO GAVILAN
JOSE MANUEL ENTRENA FERNANDEZ
EDUARDO FERNANDEZ SEGURA
RAFAEL GALVEZ MATEOS
RAFAEL GONZALEZ CANO
ANA MARIA JIMENEZ GARCIA
Mª INMACULADA ROSA MONTES RAMIREZ
FRANCISCO RAFAEL NIETO LOPEZ
DANIEL PEREZ BARTIVAS
LUCIA ROMERO MARTINEZ
LEANDRO RUIZ LEYVA
MARIA DEL CARMEN RUIZ CANTERO
AHMAD AGIL ABDALLA
ANTONIA ARTACHO CORDON
JOSE MANUEL BAEYENS CABRERA
FRANCISCO JAVIER CAÑIZARES GARCIA
CRUZ MIGUEL CENDAN MARTINEZ
ENRIQUE JOSE COBOS DEL MORAL
Prevalence and risk factors associated with fatal adverse drug reactions among patients admitted at a Spanish teaching hospital
EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2019;
FI:3,66; Q1
Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation
FRONTIERS IN PHARMACOLOGY, 2019;
FI:3,845; Q1
Potential drug-drug interactions in deceased inpatients
INTERNAL AND EMERGENCY MEDICINE, 2019;
FI:2,335; Q2
Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and sigma(1) receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019;
FI:4,833; D1
A novel nanoformulation of PLGA with high non-ionic surfactant content improves in vitro and in vivo PTX activity against lung cancer
PHARMACOLOGICAL RESEARCH, 2019;
FI:5,574; D1
Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists
PHARMACOLOGICAL RESEARCH, 2018;
FI:4,897; D1
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties
JOURNAL OF MEDICINAL CHEMISTRY, 2018;
FI:6,253; D1
Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile
JOURNAL OF MEDICINAL CHEMISTRY, 2018;
FI:6,253; D1
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic sigma Receptor Ligands with Exocyclic Amino Moiety
JOURNAL OF MEDICINAL CHEMISTRY, 2018;
FI:6,253; D1
Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling
CELL REPORTS, 2018;
FI:8,032; Q1
Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation
SCIENTIFIC REPORTS, 2017;
FI:4,259; Q1
Opioids and immunosupression in oncological postoperative patients
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2017;
FI:0,931; Q3
Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia
NEUROPHARMACOLOGY, 2017;
FI:5,012; D1
Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017;
FI:9,661; D1
Paclitaxel-loaded hollow-poly(4-vinylpyridine) nanoparticles enhance drug chemotherapeutic efficacy in lung and breast cancer cell lines
NANO RESEARCH, 2017;
FI:7,354; D1
Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin
SCIENTIFIC REPORTS, 2016;
FI:5,228; Q1
Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells
SCIENTIFIC REPORTS, 2016;
FI:5,228; Q1
Distinguishing subgroups among mu-opioid receptor agonists using Na+,K+-ATPase as an effector mechanism
EUROPEAN JOURNAL OF PHARMACOLOGY, 2016;
FI:2,73; Q2
Analysis of food advertising to children on Spanish television: probing exposure to television marketing
ARCHIVES OF MEDICAL SCIENCE, 2016;
FI:1,812; Q2
Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)
BMC PUBLIC HEALTH, 2016;
FI:2,209; Q2
Trends in the dispensation of antidepressant drugs over the past decade (2000-2010) in Andalusia, Spain
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY, 2015;
FI:2,537; Q2
Use of Very-Low-Dose Methadone and Haloperidol for Pain Control in Palliative Care Patients: Are the Sigma-1 Receptors
JOURNAL OF PALLIATIVE MEDICINE, 2015;
FI:1,912; Q2
Maternal PPARG Pro12Ala polymorphism is associated with infant’s neurodevelopmental outcomes at 18 months of age
EARLY HUMAN DEVELOPMENT, 2015;
FI:1,785; Q2
Seroprevalence of Leishmania infection among asymptomatic renal transplant recipients from southern Spain
TRANSPLANT INFECTIOUS DISEASE, 2015;
FI:2,064; Q3
Sigma-1 receptor and inflammatory pain
INFLAMMATION RESEARCH, 2015;
FI:2,347; Q3
Evaluación de la Eficacia Analgésica de Un Nuevo Sistema Electromagnético Transcutáneo en Patologías Asociadas A Dolor Neuropático Periferico
Financiador: CONSEJERÍA DE SALUD
Número de expediente: PIN-0505-2016
Tiempo de ejecución: 01/01/2017 - 31/12/2018
IP: RAFAEL GALVEZ MATEOS
Estudio aleatorizado, doble ciego, controlado con un placebo y en grupos paralelos para evaluar la eficacia y la seguridad del BIIB074 ensujetos condolor neuropatico por radiculopatia lumbosacra
Financiador: CONVERGENCE PHARMACEUTICALS LIMITED
Tipo de prueba: ENSAYO CLINICO COMERCIAL
Tiempo de ejecución: 20/04/2017 - 30/05/2018
IP: RAFAEL GALVEZ MATEOS
An Uncontrolled, Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Maintenance of Effect of BIIB074 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy
Financiador: BIOGEN IDEC LIMITED
Tipo de prueba: ENSAYO CLINICO COMERCIAL
Tiempo de ejecución: 08/11/2017 - 30/04/2019
IP: RAFAEL GALVEZ MATEOS
Ensayo doble ciego, controlado con placebo, aleatorizado, de busquedad de dosis para determinar la seguridad y eficacia de tres niveles de dosis de EMA401 para reducir la puntuacion de intensidad del dolor promedio a las 24 horas en pacientes con neuralgia posherpetica (EMPHENE)
Financiador: NOVARTIS FARMACEUTICA, S.A.
Tipo de prueba: ENSAYO CLINICO COMERCIAL
Tiempo de ejecución: 21/07/2017 - 30/09/2019
IP: RAFAEL GALVEZ MATEOS