MP13-Resistencias a Antiretrovirales

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The group coordinates the Spanish HIV Research Network Work Package on subtypes and resistance and contributes with several European organizations on HIV resistance (ESAR-SPREAD, Eurocord-CHAIN, EuRESIST-INTEGRATE) and hepatitis resistance (SHARED, HEPCARE). The group has been actively involved in recent research on Transmitted Drug Resistance in Spain and Europe, on genotypic investigation on HIV viral Tropism, on clinical significance of HIV low and very low-level viraemia, and on molecualr epidemiology of HIV ti guide public helath interventions. The group is actively involved in hepatitis C virus research activities, coordianting several activities in GEHEP (Spanish Viral Hepatitis Study Group of the Clinical Microbiology & Infectious diseases Spanish Society), and coordinator of HEPCRESP, the Spanish national cohort on HCV resistance to new DAAs. The group is also in the Sterring Comittee of HEPCARE (Europe) and SHARED (Global) hepatitis

Líneas de investigación

Eliminación de hepatitis C
Epidemiología molecular de VIH
Microbiota e inmunomodulación
Microbiota y enfermedad
Microbiota y probióticos
Resistencias a Antirretrovirales
Resistencias en VHC

Palabras clave

VIH, Hepatitis C, Microbiota.

Mª DOLORES MERIDA DEL CAÑO

ALEJANDRO PEÑA MONJE

JOSE ANTONIO SANCHEZ ALVAREZ

MARTA ALVAREZ ESTEVEZ

ANTONIO BARRIENTOS DURAN

ORCID

NATALIA CHUECA PORCUNA

ADOLFO DE SALAZAR GONZALEZ

ANA FUENTES LOPEZ

FEDERICO GARCIA GARCIA

FERNANDO GARCIA GARCIA

CARLOS GERRERO BELTRAN

JOSEFA LOPEZ BUENO

Llerena, S; Cabezas, J; Cuadrado, A; Olmos, JM; Gonzalez, M; Garcia, F; Cobo, C; Crespo, J

Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done

ANNALS OF HEPATOLOGY, 2019;

FI:1,895; Q4

Crespo, J; Eiros-Bouza, JM; Blasco-Bravo, AJ; Lazaro-de-Mercado, P; Aguilera-Guirao, A; Garcia, F; Garcia-Samaniego-Rey, J; Calleja-Panero, JL

The efficiency of several one-step testing strategies for the diagnosis of hepatitis C

REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, 2019;

FI:1,858; Q4

Ramos-Martinez, A; Calderon-Parra, J; Miro, JM; Munoz, P; Rodriguez-Abella, H; Valerio, M; de Alarcon, A; Luque, R; Ambrosioni, J; Farinas, MC; Goenaga, MA; Oteo, JA; Marcos, FJM; Vinuesa, D; Dominguez, F; Sanchez, FF; Noureddine, M; Rosas, G; Lima, JD; Aramendi, J; Blanco, MJ; Blanco, R; Boado, MV; Lazaro, MC; Crespo, A; Goikoetxea, J; Iruretagoyena, JR; Zuazabal, JI; Lopez-Soria, L; Montejo, M; Nieto, J; Rodrigo, D; Rodriguez, D; Rodriguez, R; Vitoria, Y; Voces, R; Lopez, MVG; Georgieva, RI; Ojeda, G; Bailon, IR; Morales, JR; Cuende, AM; Echeverria, T; Fuerte, A; Gaminde, E; Goenaga, MA; Idigoras, P; Iribarren, JA; Yarza, AI; Urkola, XK; Reviejo, C; Carrasco, R; Climent, V; Llamas, P; Merino, E; Plazas, J; Reus, S; Alvarez, N; Bravo-Ferrer, JM; Castelo, L; Cuenca, J; Llinares, P; Rey, EM; Mayo, MR; Sanchez, E; Regueiro, DS; Martinez, FJ; Alonso, MD; Castro, B; Rosado, DG; Duran, MD; Gomez, MAM; Lacalzada, J; Nassar, I; Ciezar, AP; Iglesias, JMR; Alvarez, VA; Costas, C; de la Hera, J; Suarez, JF; Fraile, LI; Arguero, VL; Menendez, JL; Bajo, PM; Morales, C; Torrico, AM; Palomo, C; Martinez, BP; Esteban, AR; Garcia, RR; Asensio, MT; Almela, M; Ambrosioni, J; Azqueta, M; Brunet, M; Bodro, M; Cartana, R; Falces, C; Fita, G; Fuster, D; de la Maria, CG; Hernandez-Meneses, M; Perez, JL; Marco, F; Miro, JM; Moreno, A; Nicolas, D; Ninot, S; Quintana, E; Pare, C; Pereda, D; Pericas, JM; Pomar, JL; Ramirez, J; Rovira, I; Sandoval, E; Sitges, M; Soy, D; Tellez, A; Tolosana, JM; Vidal, B; Vila, J; Adan, I; Bermejo, J; Bouza, E; Celemin, D; Caballero, GC; Montero, AD; Cruz, AF; Mansilla, AG; Leoni, MEG; Ramallo, VG; Hernandez, MK; Hualde, AM; Marin, M; Martinez-Selles, M; Menarguez, MC; Munoz, P; Rincon, C; Rodriguez-Abella, H; Rodriguez-Creixems, M; Pinilla, B; Pinto, A; Valerio, M; Vazquez, P; Moreno, EV; Antorrena, I; Loeches, B; Quiros, AM; Moreno, M; Ramirez, U; Baston, VR; Romero, M; Saldana, A; Balbin, JA; Castillo, CA; Arnaiz, A; de las Revillas, FA; Belaustegui, MC; Farinas, MC; Farinas-Alvarez, C; Izquierdo, RG; Garcia, I; Rico, CG; Gutierrez-Cuadra, M; Diez, JG; Pajaron, M; Parra, JA; Teira, R; Zarauza, J; Dominguez, F; Pavia, PG; Gonzalez, J; Orden, B; Ramos, A; Centella, T; Hermida, JM; Moya, JL; Martin-Davila, P; Navas, E; Oliva, E; del Rio, A; Ruiz, S; Tenorio, CH; Delia, MA; Araji, O; Barquero, JM; Jambrina, RC; de Cueto, M; Acebal, JG; Mendez, I; Morales, I; Lopez-Cortes, LE; de Alarcon, A; Garcia, E; Haro, JL; Lepe, JA; Lopez, F; Luque, R; Alonso, LJ; Azcarate, P; Gutierrez, JMA; Blanco, JR; Villegas, AC; Garcia-Alvarez, L; Oteo, JA; Sanz, M; de Benito, N; Gurgui, M; Pacho, C; Pericas, R; Pons, G; Alvarez, M; Fernandez, AL; Martinez, A; Prieto, A; Regueiro, B; Tijeira, E; Vega, M; Blasco, AC; Mollar, JC; Arana, JCG; Uriarte, OG; Lopez, AM; de Zarate, ZO; Matos, JAU; Gloria, GD; Antonio, SP; Leal, JMA; Vazquez, EG; Torres, AH; Blazquez, A; Valenzuela, GD; Alonso, A; Aramburu, J; Calvo, FE; Rodriguez, AM; Tarabini-Castellani, P; Galvez, EH; Bellido, CM; Pau, JL; Sepulveda, MA; Sierra, PT; Iqbal-Mirza, SZ; Alcolea, EC; Yanez, IK; Ballesta, AP; Escobar, EM; Monje, AP; Cabrera, VS; Garcia, DV; Asenjo, MA; Luna, CC; Morcillo, JN; Seco, MCP; Villoslada, A; Guallar, A; Abad, NF; Mangas, PG; Adell, MM; Ruiz, MPP; Porres, JC; Vidal, BA; Trigueros, NC; Espin, MJD; Caro, JAG; Sanchez, RJ; Almazan, AJ; Freire, AO; Gonzalez, MV; Ramis, PP; Blanco, MAR; Bordes, ERD; Bonet, LV; Munera, MCB; Garaizabal, EE; Martinez, AT; Luque, JCS

Effect of the type of surgical indication on mortality in patients with infective endocarditis who are rejected for surgical intervention

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2019;

FI:3,471; Q2

Rusanova, I; Fernandez-Martinez, J; Fernandez-Ortiz, M; Aranda-Martinez, P; Escamesa, G; Garcia-Garcia, FJ; Manas, L; Acuna-Castroviejo, D

Involvement of plasma miRNAs, muscle miRNAs and mitochondrial miRNAs in the pathophysiology of frailty

EXPERIMENTAL GERONTOLOGY, 2019;

FI:3,08; Q2

Plaza-Diaz, J; Alvarez-Mercado, AI; Ruiz-Marin, CM; Reina-Perez, I; Perez-Alonso, AJ; Sanchez-Andujar, MB; Torne, P; Gallart-Aragon, T; Sanchez-Barron, MT; Lartategui, SR; Garcia, F; Chueca, N; Moreno-Delgado, A; Torres-Martinez, K; Saez-Lara, MJ; Robles-Sanchez, C; Fernandez, MF; Fontana, L

Association of breast and gut microbiota dysbiosis and the risk of breast cancer: a case-control clinical study

BMC CANCER, 2019;

FI:2,933; Q3

Cuenca-Barrales, C; De Salazar, A; Chueca, N; Saenz-Guirado, S; Ruiz-Villaverde, R

Phaeohyphomycosis due to Pleurostomophora richardsiae: an uncommon cutaneous fungal infection

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2018;

FI:4,287; Q1

Colagrossi, L; Hermans, LE; Salpini, R; Di Carlo, D; Pas, SD; Alvarez, M; Ben-Ari, Z; Boland, G; Bruzzone, B; Coppola, N; Seguin-Devaux, C; Dyda, T; Garcia, F; Kaiser, R; Kose, S; Krarup, H; Lazarevic, I; Lunar, MM; Maylin, S; Micheli, V; Mor, O; Paraschiv, S; Paraskevis, D; Poljak, M; Puchhammer-Stockl, E; Simon, F; Stanojevic, M; Stene-Johansen, K; Tihic, N; Trimoulet, P; Verheyen, J; Vince, A; Lepej, SZ; Weis, N; Yalcinkaya, T; Boucher, CAB; Wensing, AMJ; Perno, CF; Svicher, V

Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe

BMC INFECTIOUS DISEASES, 2018;

FI:2,62; Q2

Rojas-Feria, M; Romero-Garcia, T; Caballero-Rico, JAF; Ramirez, HP; Aviles-Recio, M; Castro-Fernandez, M; Porcuna, NC; Romero-Gomez, M; Garcia, F; Grande, L; Del Campo, JA

Modulation of faecal metagenome in Crohn’s disease: Role of microRNAs as biomarkers

WORLD JOURNAL OF GASTROENTEROLOGY, 2018;

FI:3,3; Q2

Rico, JAFC; Porcuna, NC; Estevez, MA; Gutierrez, MDM; Maeso, MAM; Garcia, F

A safe an easy method for building consensus HIV sequences from 454 massively parallel sequencing data

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2018;

FI:1,707; Q3

Kostaki, EG; Karamitros, T; Bobkova, M; Oikonomopoulou, M; Magiorkinis, G; Garcia, F; Hatzakis, A; Paraskevis, D

Spatiotemporal Characteristics of the HIV-1 CRF02_AG/CRF63_02A1 Epidemic in Russia and Central Asia

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2018;

FI:1,935; Q3

Arboledas, JCA; Guerrero, IP; Rodriguez, MJB; Martos, ET; Perez, AB; Leon, CC; Sanchez, JFS; Prieto, MDL; Porcuna, NC; Mochon, MDO; Macias, J; Salgado, AD; Granger, JR; Fernandez, MD; Lozano, IG; Ramirez, ER; Rivero, A; Dominguez, MDL; Viciana, I; Montemayor, JCG; Garcia, FG

Hepatitis C virus core antigen in the management of patients treated with new direct-acting antivirals

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2017;

FI:2,401; Q3

Rhee, SY; Varghese, V; Holmes, SP; Van Zyl, GU; Steegen, K; Boyd, MA; Cooper, DA; Nsanzimana, S; Saravanan, S; Charpentier, C; de Oliveira, T; Etiebet, MAA; Garcia, F; Goedhals, D; Gomes, P; Gunthard, HF; Hamers, RL; Hoffmann, CJ; Hunt, G; Jiamsakul, A; Kaleebu, P; Kanki, P; Kantor, R; Kerschberger, B; Marconi, VC; Ndahimana, JD; Ndembi, N; Ngo-Giang-Huong, N; Rokx, C; Santoro, MM; Schapiro, JM; Schmidt, D; Seu, L; Sigaloff, KCE; Sirivichayakul, S; Skhosana, L; Sunpath, H; Tang, M; Yang, CF; Carmona, S; Gupta, RK; Shafer, RW

Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration

EBIOMEDICINE, 2017;

Rodriguez-Nogales, A; Algieri, F; Garrido-Mesa, J; Vezza, T; Utrilla, MP; Chueca, N; Garcia, F; Olivares, M; Rodriguez-Cabezas, ME; Galvez, J

Differential intestinal anti-inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition

MOLECULAR NUTRITION & FOOD RESEARCH, 2017;

FI:4,323; D1

Aguilera, A; Navarro, D; Rodriguez-Frias, F; Viciana, I; Martinez-Sapina, AM; Rodriguez, MJ; Martro, E; Lozano, MC; Coletta, E; Cardenoso, L; Suarez, A; Trigo, M; Rodriguez-Granjer, J; Montiel, N; de la Iglesia, A; Alados, JC; Vegas, C; Bernal, S; Fernandez-Cuenca, F; Pena, MJ; Reina, G; Garcia-Bujalance, S; Echevarria, MJ; Benitez, L; Perez-Castro, S; Ocete, D; Garcia-Arata, I; Guerrero, C; Rodriguez-Iglesias, M; Casas, P; Garcia, F

Prevalence and distribution of hepatitis C virus genotypes in Spain during the 2000-2015 period (the GEHEP 005 study)

JOURNAL OF VIRAL HEPATITIS, 2017;

FI:4,122; Q1

Perez-Parra, S; Chueca, N; Alvarez, M; Pasquau, J; Omar, M; Collado, A; Vinuesa, D; Lozano, AB; Yebra, G; Garcia, F

High prevalence and diversity of HIV-1 non-B genetic forms due to immigration in southern Spain: A phylogeographic approach

PLOS ONE, 2017;

FI:2,806; Q1

Rodriguez-Perez, C; Quirantes-Pine, R; Uberos, J; Jimenez-Sanchez, C; Pena, A; Segura-Carretero, A

Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli

FOOD & FUNCTION, 2016;

FI:2,686; Q1

Fernandez-Caballero, JA; Chueca, N; Alvarez, M; Merida, MD; Lopez, J; Sanchez, JA; Vinuesa, D; Martinez, MA; Hernandez, J; Garcia, F

Usefulness of Integrase resistance testing in proviral HIV-1 DNA in patients with Raltegravir prior failure

BMC INFECTIOUS DISEASES, 2016;

FI:2,69; Q2

Garcia, ET; Sanz, GY; Llacer-Delicado, T; Garcia, RR; Gonzalez-Garcia, J; Garcia, FG; Lopez-Aldeguere, J; Alvarez, VA; Fernandez, AH

Clinical, epidemiological and treatment failure data among HIV-1 non-B-infected patients in the Spanish AIDS Research Network Cohort

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2016;

FI:1,53; Q3

Hermans, LE; Svicher, V; Pas, SD; Salpini, R; Alvarez, M; Ben Ari, Z; Boland, G; Bruzzone, B; Coppola, N; Seguin-Devaux, C; Dyda, T; Garcia, F; Kaiser, R; Kose, S; Krarup, H; Lazarevic, I; Lunar, MM; Maylin, S; Micheli, V; Mor, O; Paraschiv, S; Paraskevis, D; Poljak, M; Puchhammer-Stockl, E; Simon, F; Stanojevic, M; Stene-Johansen, K; Tihic, N; Trimoulet, P; Verheyen, J; Vince, A; Weis, N; Yalcinkaya, T; Lepej, SZ; Perno, C; Boucher, CAB; Wensing, AMJ

Combined Analysis of the Prevalence of Drug-Resistant Hepatitis B Virus in Antiviral Therapy-Experienced Patients in Europe (CAPRE)

JOURNAL OF INFECTIOUS DISEASES, 2016;

FI:6,344; D1

Brenner, BG; Thomas, R; Blanco, JL; Ibanescu, RI; Oliveira, M; Mesplede, T; Golubkov, O; Roger, M; Garcia, F; Martinez, E; Wainberg, MA

Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016;

FI:4,919; D1

Poveda, E; Wyles, D; Morano, L; Pineda, JA; Garcia, F

News on HIV-HCV Coinfection: Update From the 2015 GEHEP Conference

AIDS REVIEWS, 2015;

FI:3,787; Q2

Llibre, JM; Pulido, F; Garcia, F; Deltoro, MG; Blanco, JL; Delgado, R

Genetic Barrier to Resistance for Dolutegravir

AIDS REVIEWS, 2015;

FI:3,787; Q2

Parra, D; Pena-Monje, A; Coronado-Alvarez, NM; Hernandez-Quero, J; Parra-Ruiz, J

In vitro efficacy of daptomycin and teicoplanin combined with ethanol, clarithromycin or gentamicin as catheter lock solutions

BMC MICROBIOLOGY, 2015;

FI:2,729; Q2

Plaza-Diaz, J; Fernandez-Caballero, JA; Chueca, N; Garcia, F; Gomez-Llorente, C; Saez-Lara, MJ; Fontana, L; Gil, A

Pyrosequencing Analysis Reveals Changes in Intestinal Microbiota of Healthy Adults Who Received a Daily Dose of Immunomodulatory Probiotic Strains

NUTRIENTS, 2015;

FI:3,27; Q2

Recio-Lopez, JL; Pena-Monje, A; Perez-Parra, S; Garcia-Garcia, F

In vitro sensitivity to ceftaroline of Staphylococcus aureus

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2015;

FI:2,172; Q3

Relevancia Clínica E Impacto Económico de la Correcta Asignación del Genotipo/subtipo del Virus de la Hepatitis C en la Era de Los Antivirales de Acción Directa.

Financiador: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

Número de expediente: PI-0411-2014

Tiempo de ejecución: 31/07/2015 - 30/09/2017

IP: MARTA ALVAREZ ESTEVEZ

Caracterización virológica de los pacientes que no consiguen Respuesta Viral Sostenida a tratamiento con antivirales de acción directa frente al virus de la hepatitis C en regímenes libres de interferón.

Financiador: SOCIEDAD ESPAÑOLA DE ENFERMEDADES INFECCIOSAS Y MICROBIOLOGÍA CLÍNICA

Número de expediente: GEHEP-004-FGG

Tiempo de ejecución: 04/07/2017 - 03/07/2018

IP: FEDERICO GARCIA GARCIA

Caracterización virológica de los pacientes que no consiguen Respuesta Viral Sostenida a tratamiento con Antivirales de acción Directa frente al Virus de la Hepatitis C

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI15/00713

Tiempo de ejecución: 01/01/2016 - 31/12/2018

IP: FEDERICO GARCIA GARCIA

Implantación de Una Aplicación Web para la Monitorización y Caracterización A Tiempo Real de Los Clusters Con Alta Tasa de Transmisión del Vih en Andalucía Oriental

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PI-0550-2017

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: MARTA ALVAREZ ESTEVEZ

RD16/0025/0040 – RED SIDA- FEDERICO GARCÍA GARCÍA

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: RD16/0025/0040

Tiempo de ejecución: 01/01/2017 - 31/12/2021

IP: FEDERICO GARCIA GARCIA

VIGILANCIA EPIDEMIOLOGICA DE LAS RESISTENCIAS PRIMARIAS Y TRASMITIDAS A LOS ANTIRETROVIRALES EN ESPAÑA. ESTUDIO FILOGENÉTICO, FILODINAMICO Y FILOETNICO

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI18/00819

Tiempo de ejecución: 01/01/2019 - 31/12/2021

IP: FEDERICO GARCIA GARCIA

MP13-Resistencias a Antiretrovirales

Líneas de investigación

Palabras clave

Mª DOLORES MERIDA DEL CAÑO

ALEJANDRO PEÑA MONJE

JOSE ANTONIO SANCHEZ ALVAREZ

MARTA ALVAREZ ESTEVEZ

ANTONIO BARRIENTOS DURAN

NATALIA CHUECA PORCUNA

ADOLFO DE SALAZAR GONZALEZ

ANA FUENTES LOPEZ

FEDERICO GARCIA GARCIA

FERNANDO GARCIA GARCIA

CARLOS GERRERO BELTRAN

JOSEFA LOPEZ BUENO

Investigación