TEC12-Biomecánica

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The structural microarchitecture of soft tissue is recently becoming a cornerstone of biomechanical engineering and is of growing interest for a broad spectrum of clinical specialists. Our new ultrasonic wave concepts are enabling a new class of biomarkers for both imaging and controlling in vivo and noninvasively tissue microarchitecture. The breakthrough of modelling its elastic hierarchical complexity impacts critical aspects including organ-level functionality, inflammatory and healing processes, tumour growth, all the way down to cell-to-cell signalling. We have: a) Conceived and developed torsional ultrasonic waves and sensor technologies capable of generating and sensing them, prototyping robust functional instrumentation. b) Modelled relationships between the biochemical cascade and the mechanical functionality and their interaction with ultrasound, integrating models of tissue remodelling and tumour growth, experimentally validated by ultrasonication of cancer stem cells.

Líneas de investigación

Biomecánica y ensayos mecánicos de tejidos
Biorreactores sensorizados
Dispositivos médicos de diagnóstico por ultrasonidos y elastografía - aplicación a parto pretérmino
Ecografía elastográfica y de ultra-alta velocidad
Inferencia estadística, inteligencia artificial, pronóstico, decisiones, imagen
Modelos computacionales biomecánicos - elementos finitos

Palabras clave

Ultrasonidos, Ecografía, Ginecología, Elastografía, Biomecánica, Ensayos mecánicos, Ginecología, Oncología, Ondas, Biorreactores.

YOUSEF ALMASHAKBEH SALEH

PARISA REZAEIAFARAPOLI

ORCID

HIRAD SHAMIMI NOORI

OLGA OCON HERNANDEZ

CARMEN PADILLA VINUESA

MIGUEL ANGEL RIVEIRO TABOADA

GUILLERMO RUS CALBORG

JORGE TORRES PEREZ

BEATRIZ BLANCO BESTEIRO

ANTONIO CALLEJAS ZAFRA

PILAR CARRETERO LUCENA

ANTONIO GOMEZ FERNANDEZ

OTILIA RUTH GONZALEZ VANEGAS

INAS H FARIS

MANUEL HURTADO ESTEVEZ

JUAN MANUEL MELCHOR RODRIGUEZ

FRANCISCA SONIA MOLINA GARCIA

Rus, G; Melchor, J; Muller, M; Khan, AA

Biomechanical Constitutive Model Identification

MATHEMATICAL PROBLEMS IN ENGINEERING, 2019;

FI:1,179; Q3

Frade, JMO; Medina, DB; Cuevas, MB; Fernandez, MLD; Santos, TG; Ezquerra, JM; Gay, IR; Laurel, MHA; Artal, S; Bolon, A; Cabral, MD; Caron, P; Cerquiglini, B; Narbona, ID; Faria, D; Cardo, JMF; Maduell, FL; Lavou, V; Leguen, B; Morin, YC; Moureau, F; Reid, M; Baneres, AS; Segarra, M; Ramos, MAS; Thibault, A; de Toro, A; Westphal, B; Fernandez, AY; Desvaux, AP; Lanza, AG; Garcia, AA; Cano, ABS; Mendes, APC; Cenitagoya, AIL; Perez, AS; Benit, A; Robayna, AS; Pintor, AR; Calderon, AG; Hernandez, AS; Reboul, AM; Lopez, AP; Feltstrom, AA; Galan, AG; Fernandez, AG; Canas, BM; Vegh, B; Lope, BA; Leguen, B; Lanza, CG; Camprubi, CB; Perez, CC; Aguila, CC; Lepinette, B; Duee, C; Lecrivain, C; Bernal, CP; Cavalla, C; Castells, CS; Galin, DD; Faria, D; Alfaro, ER; Arjona, EM; Klett, E; Oliva, EJ; Leon, ELY; Gimeenez, ED; Ponce, EP; Bayon, ER; Minano, E; Outeirinho, F; Copello, F; Alcala, FDR; Fernandez, FG; Prados, FJD; Ales, FL; Espinar, GS; Dugas, G; Perello, HR; Las Heras, II; Ortega, II; Valles, IT; Solana, IA; Rey, IG; Hoghton, IB; Moreels, I; Martinez, IM; Delahaie, JV; Guijarro, JD; Lopez, JS; Bourdin, JC; Cuadrado, JM; Arribas, JC; Molina, JV; Fernandez, JA; Vega, JJVY; Almeida, JD; Ilobregat, JLA; Goya, JML; Cardo, JMF; Frias, JY; Alonso, JB; Bascunana, JFG; Cecilia, JH; Salcedo, JJ; Munoz, JML; Boleka, JB; Serrano, LP; Marois, L; Bustamante, LA; Vendrell, LA; Millet, LB; Lopez, LC; Gonzalez, LP; Bonilla, LR; Jimenez, LV; Cabrol, MCF; Campora, M; de Avila, MG; Castillo, MT; Dorronsoro, MB; Lopez, MDG; Romero, MDM; Gonzalez, MDP; dos Santos, MDGR; Keating, ME; Guerrero, MJH; Gonzalez, MLP; Malato, ML; Pascual, MPS; Sampedro, MTL; Martinez, ML; Robles, MO; Montaner, MS; Renouprez, M; Cavero, ME; de Arrieta, MM; Diaz, ML; Ivanez, MP; Manes, MS; Roelens, N; Vuelta, NI; Parenteau, O; Garcia, PM; Huerta, PM; Jimenez, PP; Sole, PS; Boue, PA; Alvarez, RR; Maia, RB; Mirza, R; Martinez, RD; Araujo, SLG; Alarcon, SD; Artal, S; Hernandez, TS; Martinez, TA; Nogales, VEM; Lavou, V; Silvestre, YBJ

News from cedille (evaluation, deadlines, statistics, databases, panel of evaluators …)

CEDILLE-REVISTA DE ESTUDIOS FRANCESES, 2019;

Callejas, A; Rus, G

Experimental Configuration to Determine the Nonlinear Parameter in PMMA and CFRP with the Finite Amplitude Method

SENSORS, 2019;

FI:3,031; Q1

Masso, P; Callejas, A; Melchor, J; Molina, FS; Rus, G

In Vivo Measurement of Cervical Elasticity on Pregnant Women by Torsional Wave Technique: A Preliminary Study

SENSORS, 2019;

FI:3,031; Q1

Baena-Garcia, L; Ocon-Hernandez, O; Acosta-Manzano, P; Coll-Risco, I; Borges-Cosic, M; Romero-Gallardo, L; de la Flor-Alemany, M; Aparicio, VA

Association of sedentary time and physical activity during pregnancy with maternal and neonatal birth outcomes. The GESTAFIT Project

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2019;

FI:3,631; Q1

Rus, G; Riveiro, M; Molina, FS

Effect of Contact Conditions of Torsional Wave Elastographic Probe on Human Cervix

MATHEMATICAL PROBLEMS IN ENGINEERING, 2018;

FI:1,145; Q3

Rolnik, DL; Wright, D; Poon, LC; O'Gorman, N; Syngelaki, A; Matallana, CD; Akolekar, R; Cicero, S; Janga, D; Singh, M; Molina, FS; Persico, N; Jani, JC; Plasencia, W; Papaioannou, G; Tenenbaum-Gavish, K; Meiri, H; Gizurarson, S; Maclagan, K; Nicolaides, KH

Aspirin Versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

OBSTETRICAL & GYNECOLOGICAL SURVEY, 2018;

FI:2,014; Q3

Munoz, R; Melchor, J

Nonlinear Classical Elasticity Model for Materials with Fluid and Matrix Phases

MATHEMATICAL PROBLEMS IN ENGINEERING, 2018;

FI:1,145; Q3

Rus, G; Melchor, J

Logical Inference Framework for Experimental Design of Mechanical Characterization Procedures

SENSORS, 2018;

FI:2,475; Q1

Aranda, E; Garcia-Alfonso, P; Benavides, M; Ruiz, AS; Guillen-Ponce, C; Safont, MJ; Alcaide, J; Gomez, A; Lopez, R; Manzano, JL; Urena, MM; Sastre, J; Rivera, F; Gravalos, C; Garcia, T; Martin-Valades, JI; Falco, E; Navalon, M; Flores, EG; Tapiador, AMG; Munoz, AML; Barrajon, E; Reboredo, M; Teijido, PG; Viudez, A; Cardenas, N; Diaz-Rubio, E

First-line mFOLFOX plus cetuximab followed by mFOLFOX plus cetuximab or single-agent cetuximab as maintenance therapy in patients with metastatic colorectal cancer: Phase II randomised MACRO2 TTD study

EUROPEAN JOURNAL OF CANCER, 2018;

FI:7,191; Q1

Segura, MT; Demmelmair, H; Krauss-Etschmann, S; Nathan, P; Dehmel, S; Padilla, MC; Rueda, R; Koletzko, B; Campoy, C

Maternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition

PLACENTA, 2017;

FI:2,759; Q1

Guevara, EG; Pazos, A; Gonzalez, O; Carretero, P; Molina, FS

Doppler assessment of patients with twin-to-twin transfusion syndrome and survival following fetoscopic laser surgery

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2017;

FI:2,174; Q2

Trama, A; Marcos-Gragera, R; Perez, MJS; van der Zwan, JM; Ardanaz, E; Bouchardy, C; Melchor, JM; Martinez, C; Capocaccia, R; Vicentini, M; Siesling, S; Gatta, G

Data quality in rare cancers registration: the report of the RARECARE data quality study

TUMORI, 2017;

FI:1,233; Q4

Lopez-Ruiz, E; Venkateswaran, S; Peran, M; Jimenez, G; Pernagallo, S; Diaz-Mochon, JJ; Tura-Ceide, O; Arrebola, F; Melchor, J; Soto, J; Rus, G; Real, PJ; Diaz-Ricart, M; Conde-Gonzalez, A; Bradley, M; Marchal, JA

Poly(ethylmethacrylate-co-diethylaminoethyl acrylate) coating improves endothelial repopulation, bio-mechanical and anti-thrombogenic properties of decellularized carotid arteries for blood vessel replacement

SCIENTIFIC REPORTS, 2017;

FI:4,259; Q1

Rolnik, DL; Wright, D; Poon, LCY; Syngelaki, A; O'Gorman, N; Matallana, CD; Akolekar, R; Cicero, S; Janga, D; Singh, M; Molina, FS; Persico, N; Jani, JC; Plasencia, W; Papaioannou, G; Tenenbaum-Gavish, K; Nicolaides, KH

ASPRE trial: performance of screening for preterm pre-eclampsia

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;

FI:4,71; D1

Gomez, A; Rus, G; Saffari, N

Use of shear waves for diagnosis and ablation monitoring of prostate cancer: a feasibility study

14TH ANGLO-FRENCH PHYSICAL ACOUSTICS CONFERENCE (AFPAC2015), 2016;

Rus, G; Munoz, R; Melchor, J; Molina, R; Callejas, A; Riveiro, M; Masso, P; Torres, J; Moreu, G; Molina, F; Gonzalez, O; Carretero, P; Padilla, C

Torsion ultrasonic sensor for tissue mechanical characterization

2016 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 2016;

Maiz, N; Alonso, I; Belar, M; Burgos, J; Irasarri, A; Molina, FS; de Paco, C; Pijoan, JI; Plasencia, W; Rodo, C; Rodriguez, MA; Tajada, M; Tubau, A

Three dimensional ultrasonography for advanced neurosonography (Neurosofe-3d). Analysis of acquisition-related factors influencing the quality of the brain volumes

PRENATAL DIAGNOSIS, 2016;

FI:3,043; Q1

Messineo, MG; Rus, G; Elicabe, GE; Frontini, GL

Layered material characterization using ultrasonic transmission. An inverse estimation methodology

ULTRASONICS, 2016;

FI:1,954; Q1

Martino, J; Sebert, S; Segura, MT; Garcia-Valdes, L; Florido, J; Padilla, MC; Marcos, A; Rueda, R; McArdle, HJ; Budge, H; Symonds, ME; Campoy, C

Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016;

FI:5,531; Q1

Dispositivo de diagnóstico de cáncer de próstata por ondas mecánicas.

Financiador: FUNDACIÓN PÚBLICA PARA LA INVESTIGACIÓN BIOSANITARIA DE ANDALUCIA ORIENTAL ALEJANDRO OTERO (FIBAO)

Número de expediente: INB-0010

Tiempo de ejecución: 10/06/2017 - 09/06/2019

IP: GUILLERMO RUS CALBORG

PI16/00339 PREDICCIÓN DEL PARTO POR ELASTOGRAFÍA ULTRASÓNICA

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI16/00339

Tiempo de ejecución: 01/01/2017 - 31/12/2019

IP: FRANCISCA SONIA MOLINA GARCIA

Ultrasonidos de Torsión para Diagnóstico de Parto Pretérmino y Predicción del Éxito en la Inducción.

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PI-0107-2017

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: JUAN MANUEL MELCHOR RODRIGUEZ

Dispositivo para Predicción de Parto Mediante el Desarrollo Tecnológico de Un Sensor Ultrasónico de Torsión.

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PIN-0030-2017

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: Dispositivo para Predicción de Parto Mediante el Desarrollo Tecnológico de Un Sensor Ultrasónico de Torsión.

Impacto de la detección y tratamiento precoz de las gestantes portadoras asintomáticas de vaginosis bacteriana, en la tasa de parto pretérmino (VB-PREM)

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI17/01881

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: OTILIA RUTH GONZALEZ VANEGAS

Líneas de investigación

Palabras clave

YOUSEF ALMASHAKBEH SALEH

PARISA REZAEIAFARAPOLI

HIRAD SHAMIMI NOORI

OLGA OCON HERNANDEZ

CARMEN PADILLA VINUESA

MIGUEL ANGEL RIVEIRO TABOADA

GUILLERMO RUS CALBORG

JORGE TORRES PEREZ

BEATRIZ BLANCO BESTEIRO

ANTONIO CALLEJAS ZAFRA

PILAR CARRETERO LUCENA

ANTONIO GOMEZ FERNANDEZ

OTILIA RUTH GONZALEZ VANEGAS

INAS H FARIS

MANUEL HURTADO ESTEVEZ

JUAN MANUEL MELCHOR RODRIGUEZ

FRANCISCA SONIA MOLINA GARCIA

Investigación